Potassium voltage-gated channel subfamily B member 2 (Kcnb2) is a 907-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q63099.
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The mean pLDDT of this model is 60.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 28% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 49% |
What pLDDT means and how to read it
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells (PubMed:1550672). Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed:1550672, PubMed:20202934, PubMed:9305895). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties…
Homotetramer or heterotetramer with KCNB1 (PubMed:20202934). Heterotetramer with KCNS1 and KCNS2 (PubMed:9305895). Interacts (via phosphorylated FFAT motif) with VAPA and VAPB (By similarity)
Cell membrane, Perikaryon, Cell projection, dendrite
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6EBL | EM | 3.0 Å | B/D/F/H=278-311 |
| 6EBK | EM | 3.3 Å | B/D/F/H=278-311 |
| 6EBM | EM | 4.0 Å | B/D/F/H=278-311 |
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