DDB1- and CUL4-associated factor 15 (DCAF15) is a 600-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q66K64.
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The mean pLDDT of this model is 77.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 52% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
Substrate-recognition component of the DCX(DCAF15) complex, a cullin-4-RING E3 ubiquitin-protein ligase complex that mediates ubiquitination and degradation of target proteins (PubMed:16949367, PubMed:31452512). The DCX(DCAF15) complex acts as a regulator of the natural killer (NK) cells effector functions, possibly by mediating ubiquitination and degradation of cohesin subunits SMC1A and SMC3 (PubMed:31452512). May play a role in the activation of antigen-presenting cells (APC) and their interaction with NK cells (PubMed:31452512)
Component of the DCX(DCAF15) complex, also named CLR4(DCAF15) complex, composed of DCAF15, DDB1, cullin-4 (CUL4A or CUL4B), DDA1 and RBX1
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6UD7 | X-ray | 2.3 Å | A=2-600 |
| 6UE5 | X-ray | 2.61 Å | A=2-600 |
| 6PAI | X-ray | 2.9 Å | C=2-600 |
| 6Q0R | X-ray | 2.9 Å | B=34-260, C=383-600 |
| 6Q0V | X-ray | 2.9 Å | B=34-260, C=383-600 |
| 6Q0W | X-ray | 2.9 Å | B=34-260, C=383-600 |
| 8ROY | EM | 3.1 Å | A=1-600 |
| 8ROX | EM | 3.3 Å | A=1-600 |
| 6SJ7 | EM | 3.54 Å | A=1-600 |
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