Tubulin beta-2B chain (TUBB2B) is a 445-residue protein from Bos taurus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q6B856.
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The mean pLDDT of this model is 92.2 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 83% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:2207090, PubMed:6504138, PubMed:7704569). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:2207090, PubMed:6504138, PubMed:7704569). Implicated in neuronal migration (By similarity)
Dimer of alpha and beta chains (PubMed:2207090, PubMed:6504138, PubMed:7704569). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural…
Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6S8K | X-ray | 1.52 Å | B=1-445 |
| 8QL2 | X-ray | 1.7 Å | B=1-445 |
| 6ZWB | X-ray | 1.75 Å | B=1-445 |
| 4I4T | X-ray | 1.8 Å | B/D=1-445 |
| 5IYZ | X-ray | 1.8 Å | B/D=1-445 |
| 5NQU | X-ray | 1.8 Å | B=1-445 |
| 7YZ3 | X-ray | 1.8 Å | B=1-445 |
| 8QEA | X-ray | 1.8 Å | B=1-445 |
| 8QL3 | X-ray | 1.8 Å | B=1-445 |
| 8QL4 | X-ray | 1.8 Å | B=1-445 |
| 8QL5 | X-ray | 1.8 Å | B=1-445 |
| 8QL6 | X-ray | 1.8 Å | B=1-445 |
| 8QL7 | X-ray | 1.8 Å | B=1-445 |
| 8QL8 | X-ray | 1.8 Å | B=1-445 |
| 8QL9 | X-ray | 1.8 Å | B=1-445 |
| 8QLA | X-ray | 1.8 Å | B=1-445 |
| 8QLB | X-ray | 1.8 Å | B=1-445 |
| 7Z01 | X-ray | 1.82 Å | B=1-445 |
| 3DCO | EM | 1.9 Å | B=1-445 |
| 5LXT | X-ray | 1.9 Å | B/D=1-445 |
Showing 20 of 283 experimental structures (best resolution first).
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