65 kDa phosphoprotein (UL83) is a 561-residue protein from Human cytomegalovirus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: Q6SW59.
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The mean pLDDT of this model is 77.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 58% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
Counteracts the host antiviral immune response when activated and phosphorylated, by preventing host IRF3 from entering the nucleus. Also inhibits the type I interferon production by inactivating the enzymatic activity of DNA sensor CGAS without affecting STING1. Participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes
Interacts with host NCL/nucleolin. Interacts with host IFI16. Interacts with host CGAS; this interaction inhibits CGAS enzymatic activity
Virion tegument, Host nucleus, Host cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3MRB | X-ray | 1.4 Å | P=495-503 |
| 3MRD | X-ray | 1.7 Å | P=495-503 |
| 3VCL | X-ray | 1.7 Å | C=265-275 |
| 3MRC | X-ray | 1.8 Å | P=495-503 |
| 3MR9 | X-ray | 1.93 Å | P=495-503 |
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