Envelope glycoprotein H (gH) is a 742-residue protein from Human cytomegalovirus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: Q6SW67.
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The mean pLDDT of this model is 79.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 39% |
| 70 to 90 | Confident: backbone generally right | 36% |
| 50 to 70 | Low: treat with caution | 15% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis (By similarity). In human cytomegalovirus, forms two distinct complexes to mediate viral entry, a trimer and a pentamer at the surface of the virion envelope. The gH-gL-gO trimer is required for infection in fibroblasts by interacting with host PDGFRA, and in glioblastoma cells by…
Interacts with glycoprotein L (gL); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion (By similarity). Forms the envelope pentamer complex (PC) composed of gH, gL, UL128, UL130, and UL131A (PubMed:17942555, PubMed:28783665). The pentamer interacts with host NRP2 (PubMed:30057110).…
Virion membrane, Host cell membrane, Host endosome membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7LBG | EM | 2.6 Å | A=1-715 |
| 7LBF | EM | 2.8 Å | A=1-715 |
| 7LBE | EM | 2.9 Å | A=1-715 |
| 7T4Q | EM | 2.9 Å | A=1-715 |
| 5VOB | X-ray | 3.02 Å | A=1-715 |
| 7T4S | EM | 3.1 Å | A=1-715 |
| 7T4R | EM | 3.3 Å | B/K=1-715 |
| 5VOC | X-ray | 3.99 Å | A=1-715 |
| 5VOD | X-ray | 5.9 Å | A=1-715 |
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