SAGA complex subunit SUS1 (SUS1) is a 96-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q6WNK7.
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The mean pLDDT of this model is 91.3 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 76% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes (PubMed:14718168, PubMed:15311284, PubMed:18923079). SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription (PubMed:25216679, PubMed:28918903). At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and…
Component of the 1.8 MDa SAGA (Spt-Ada-Gcn5 acetyltransferase) complex, which is composed of 19 subunits TRA1, SPT7, TAF5, NGG1/ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1 (PubMed:14718168, PubMed:16855026, PubMed:18488019, PubMed:31969703). The SAGA complex is composed of 4 modules, namely the HAT (histone acetyltransferase)…
Nucleus, nucleoplasm, Cytoplasm, P-body
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3MHS | X-ray | 1.89 Å | B=1-96 |
| 4FK5 | X-ray | 2.03 Å | B=1-96 |
| 3KIK | X-ray | 2.1 Å | A/B/C/D=1-96 |
| 6AQR | X-ray | 2.1 Å | B=1-96 |
| 4WA6 | X-ray | 2.36 Å | B/F=1-96 |
| 3MHH | X-ray | 2.45 Å | B=1-96 |
| 3FWB | X-ray | 2.5 Å | C=1-96 |
| 4MBE | X-ray | 2.61 Å | C/F=1-96 |
| 4FIP | X-ray | 2.69 Å | B/F=1-96 |
| 3FWC | X-ray | 2.7 Å | C/D/G/H/K/L/O/P=1-96 |
| 3KJL | X-ray | 2.7 Å | A/B/C/D=1-96 |
| 3M99 | X-ray | 2.7 Å | C=1-96 |
| 4FJC | X-ray | 2.83 Å | B/F=1-96 |
| 4C31 | X-ray | 3.0 Å | B/E=1-96 |
| 6T9L | EM | 3.6 Å | L=1-96 |
| 4ZUX | X-ray | 3.82 Å | V/a/f/k=1-96 |
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