Zinc finger protein AEBP2 (AEBP2) is a 517-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q6ZN18.
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The mean pLDDT of this model is 61.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 5% |
| 70 to 90 | Confident: backbone generally right | 38% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 44% |
What pLDDT means and how to read it
Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:29499137, PubMed:31959557). Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137)
Self-associates (PubMed:15225548). Associates with the PRC2 complex, which consists of the core components EED, EZH1 or EZH2, SUZ12, and RBBP4, and various combinations of accessory subunits including AEBP2, JARID2, PHF19, MTF2 and EPOP (PubMed:12351676, PubMed:15225548, PubMed:29499137, PubMed:31959557). Found in a monomeric PRC2.2 (class 2) complex consisting of at least SUZ12, RBBP4, AEBP2…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5Y1U | X-ray | 2.14 Å | C/D=379-390 |
| 5WAI | X-ray | 2.9 Å | C/G=407-503 |
| 8VMI | EM | 3.1 Å | P=223-517 |
| 8VNV | EM | 3.1 Å | P=225-503 |
| 9C8U | EM | 3.1 Å | F=210-503 |
| 8FYH | EM | 3.4 Å | F/L=1-517 |
| 9DCH | EM | 3.4 Å | F/M=210-503 |
| 6C24 | EM | 3.5 Å | P=209-503 |
| 6WKR | EM | 3.5 Å | P=209-503 |
| 8VML | EM | 3.5 Å | P=223-517 |
| 8VNZ | EM | 3.5 Å | P=223-517 |
| 8EQV | EM | 3.64 Å | C=1-517 |
| 6C23 | EM | 3.9 Å | P=209-503 |
| 7KSO | EM | 3.9 Å | E=209-503 |
| 8TB9 | EM | 4.0 Å | Y=223-517 |
| 8TAS | EM | 4.1 Å | Y=224-517 |
| 8T9G | EM | 6.2 Å | M/Y=223-517 |
| 5Y0U | NMR | A=258-357 |
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