Ubiquitin-conjugating enzyme E2 R2 (UBE2R2) is a 238-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q712K3.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 85.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 69% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
E2 ubiquitin-conjugating enzyme that accepts ubiquitin from an E1 ubiquitin-activating protein, and catalyzes its covalent attachment to other proteins by an E3 ubiquitin-protein ligase complex (PubMed:12037680, PubMed:20061386, PubMed:38326650). In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination (PubMed:12037680, PubMed:20061386, PubMed:38326650). Works in collaboration with various Cul1-RING and Cul2-RING E3 ligase complexes (PubMed:38326650). May be involved in degradation of katenin (PubMed:12037680)
Interacts with multiple Cul1-RING E3 ubiquitin-protein ligase complexes, also known as SCF (SKP1-CUL1-F-box protein) complexes, including SCF(FBXW7) and SCF(BTRC) (PubMed:38326650). Interacts with multiple Cul2-RING (CRL2) E3 ubiquitin-protein ligase complexes, also known as ECS (Elongin BC-CUL2/5-SOCS-box protein) complexes, including CRL2(FEM1C) and ECS(VHL) (PubMed:38326650). When…
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6NYO | X-ray | 1.5 Å | A=1-202 |
| 8R5H | EM | 3.44 Å | C=1-192 |
| 8Q7R | EM | 3.71 Å | C=1-238 |
| 8PQL | EM | 3.76 Å | C=1-238 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.