LHFPL tetraspan subfamily member 4 protein (LHFPL4) is a 247-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q7Z7J7.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 82.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 50% |
| 70 to 90 | Confident: backbone generally right | 32% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma-aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites. Acts in concert with NLGN2 to recruit or stabilize GABAARs
Interacts with GABA(A) receptor subunits (PubMed:28978485). Identified in a complex of 720 kDa composed of LHFPL4, NLGN2, GABRA1, GABRB2, GABRG2 and GABRB3 (By similarity). Interacts with GABRB3 (By similarity). Interacts with GABRA2 (By similarity). Interacts with GABRG2 (By similarity). Interacts with GABRA1 (PubMed:28978485). Interacts with NLGN2; leading to mutual regulation of protein level…
Cell projection, dendrite, Postsynaptic cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9FAJ | EM | 2.6 Å | L=11-203 |
| 9FAK | EM | 2.6 Å | L=11-203 |
| 9FAP | EM | 2.8 Å | L=11-203 |
| 9FAN | EM | 2.9 Å | L=11-203 |
| 9FAQ | EM | 2.9 Å | L=11-203 |
| 9FAR | EM | 2.9 Å | L=11-203 |
| 9FAW | EM | 2.9 Å | L=17-203 |
| 9FAX | EM | 2.9 Å | I/L=16-203 |
| 9FAU | EM | 3.1 Å | L=16-203 |
| 9FAV | EM | 3.2 Å | L=17-201 |
| 9FAM | EM | 3.5 Å | L=11-203 |
| 9FAT | EM | 3.6 Å | L=14-203 |
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