Death-associated protein kinase 1 (Dapk1) is a 1442-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q80YE7.
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The mean pLDDT of this model is 82.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 50% |
| 70 to 90 | Confident: backbone generally right | 33% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and…
Interacts with KLHL20 (By similarity). Interacts (via death domain) with MAPK1 and MAPK3 (By similarity). Interacts with MAP1B (via N-terminus) (By similarity). Interacts with PRKD1 in an oxidative stress-regulated manner (By similarity). Interacts with PIN1, PDCD6, BECN1, TSC2 and STX1A (By similarity). Interacts (via kinase domain) with DAPK3 (via kinase domain) (By similarity). Interacts with…
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8PB1 | EM | 3.5 Å | C=301-319 |
| 8ODZ | EM | 3.6 Å | C=301-319 |
| 8OE0 | EM | 4.6 Å | C=301-319 |
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