Disrupted in schizophrenia 1 homolog (Disc1) is a 852-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q811T9.
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The mean pLDDT of this model is 63.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 27% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 46% |
What pLDDT means and how to read it
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:17825401, PubMed:19502360, PubMed:31444471). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus (PubMed:17825401, PubMed:19502360). Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance (PubMed:19303846). Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic…
Interacts with NDEL1 (PubMed:14962739). Interacts with CCDC88A (via C-terminus); the interaction is direct (PubMed:19778506). Interacts with GSK3B (PubMed:19303846). Interacts with tubulin alpha, ACTN2, ANKHD1, ATF4, ATF5, CEP63, EIF3S3, MAP1A, NDEL1, PAFAH1B1, RANBP9, SPTBN4, SYNE1 and IFT54 (By similarity). Interaction with microtubules may be mediated in part by IFT54. Interacts (via…
Cytoplasm, Cytoplasm, cytoskeleton, Mitochondrion, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Postsynaptic density
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