Tubulinyl-Tyr carboxypeptidase 2 (VASH2) is a 355-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q86V25.
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The mean pLDDT of this model is 80.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 69% |
| 70 to 90 | Confident: backbone generally right | 2% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 26% |
What pLDDT means and how to read it
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869). Critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyrosination regulates mitotic spindle length and postioning (PubMed:31171830). Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325). Plays a role in axon formation (PubMed:31235911)
Interacts with SVBP; interaction enhances VASH2 tyrosine carboxypeptidase activity
Cytoplasm, Secreted, Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6J4P | X-ray | 1.6 Å | A=46-296 |
| 6QBY | X-ray | 2.09 Å | A/C=40-295 |
| 6J4V | X-ray | 2.1 Å | A=46-296 |
| 6J4O | X-ray | 2.3 Å | A=46-296 |
| 6J4Q | X-ray | 2.7 Å | A/C/F/J=46-296 |
| 6J4S | X-ray | 2.8 Å | A=1-355 |
| 7ZCW | EM | 3.6 Å | C=1-355 |
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