Pre-glycoprotein polyprotein GP complex (GPC) is a 496-residue protein from Machupo virus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: Q8AZ57.
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The mean pLDDT of this model is 66.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 4% |
| 70 to 90 | Confident: backbone generally right | 49% |
| 50 to 70 | Low: treat with caution | 18% |
| Below 50 | Very low: often disordered regions | 29% |
What pLDDT means and how to read it
Forms the virion spikes together with glycoprotein G2. The glycoprotein spike trimers are connected to the underlying matrix. Interacts with the host receptor leading to virus endocytosis
Homotrimer; disulfide-linked. In pre-fusion state, G1 homotrimers bind G2 homotrimers via ionic interactions. Part of the GP complex (GP-C) together with glycoprotein G2 and the stable signal peptide. The GP-complex interacts with protein Z, which interacts with ribonucleocapsid; these interactions may induce virion budding
Virion membrane, Host endoplasmic reticulum membrane, Host Golgi apparatus membrane, Host cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3KAS | X-ray | 2.4 Å | B=83-244 |
| 6S9J | X-ray | 2.7 Å | B/D/F/H=85-244 |
| 9MT2 | EM | 2.9 Å | B/E/H=59-251 |
| 5W1M | X-ray | 3.91 Å | Q/R/S/T=87-238 |
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