PEX5-related protein (Pex5l) is a 567-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8C437.
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The mean pLDDT of this model is 66.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 44% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 41% |
What pLDDT means and how to read it
Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence
Interacts with RAB8B (By similarity). Forms an obligate 4:4 complex with HCN2 (PubMed:22550182). Interacts with HCN3 (Ref.5). Interacts with HCN4 with a 4:4 HCN4:PEX5L stoichiometry; reduces the effects of cAMP on the voltage-dependence and rate of activation of HCN4 (PubMed:36225302)
Cytoplasm, Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4EQF | X-ray | 3.0 Å | A=206-567 |
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