DCN1-like protein 3 (DCUN1D3) is a 304-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8IWE4.
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The mean pLDDT of this model is 79.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 62% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage (PubMed:18823379, PubMed:19617556, PubMed:23201271, PubMed:27542266). At the cell membrane, can promote and as well inhibit cullins neddylation (PubMed:19617556, PubMed:25349211, PubMed:26906416)
Part of a complex containing DCUN1D3, CUL3 and RBX1 (PubMed:19617556). Interacts (via the DCUN1 domain) with the unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5; these interactions promote the cullin neddylation and the identity of the cullin dictates the affinity of the interaction (PubMed:23201271, PubMed:26906416, PubMed:27542266). Interacts preferentially with…
Cell membrane, Cytoplasm, Nucleus, Cytoplasm, perinuclear region
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4GBA | X-ray | 2.4 Å | A/B=86-304 |
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