Tumor protein p53-inducible nuclear protein 2 (TP53INP2) is a 220-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8IXH6.
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The mean pLDDT of this model is 63.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 11% |
| 70 to 90 | Confident: backbone generally right | 16% |
| 50 to 70 | Low: treat with caution | 61% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA
Interacts with VMP1, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, MAP1LC3C and THRA
Cytoplasm, cytosol, Nucleus, Nucleus, PML body, Cytoplasmic vesicle, autophagosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8T33 | X-ray | 1.6 Å | B=31-43 |
| 7YO9 | X-ray | 1.75 Å | A=26-40 |
| 8T36 | X-ray | 1.85 Å | A=29-39 |
| 8T35 | X-ray | 1.9 Å | A/B=30-39 |
| 8T32 | X-ray | 2.05 Å | B=30-42 |
| 8T31 | X-ray | 2.1 Å | B/D/F/H/J=31-43 |
| 8T4T | X-ray | 2.36 Å | A/B=29-39 |
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