Kelch repeat and BTB domain-containing protein 2 (KBTBD2) is a 623-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8IY47.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 86.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 65% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of the insulin signaling pathway, modulating insulin sensitivity by limiting PIK3R1/p85alpha abundance in adipocytes. Targets PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase (PI3K), for 'Lys-48'-linked polyubiquitination and proteasome-mediated degradation
Component of the BCR(KBTBD2) E3 ubiquitin ligase complex, at least composed of CUL3, KBTBD2 and RBX1 (PubMed:27708159). Interacts (via the BTB domain) with CUL3 (By similarity)
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8GQ6 | EM | 3.96 Å | A/B=1-623 |
| 8H38 | EM | 4.25 Å | I/M=1-623 |
| 8H36 | EM | 4.6 Å | A/B=1-623 |
| 8H3R | EM | 6.36 Å | A/B=1-623 |
| 8H3F | EM | 6.73 Å | I/M=1-623 |
| 8H35 | EM | 7.41 Å | A/B/G/J/N/P/S/U=1-623 |
| 8H3A | EM | 7.51 Å | I/M=1-623 |
| 8H37 | EM | 7.52 Å | A/B/N/P=1-623 |
| 8H33 | EM | 7.86 Å | A/B/G/J=1-623 |
| 8H34 | EM | 7.99 Å | A/B/G/J/N/P=1-623 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.