Symplekin (Sym) is a 1165-residue protein from Drosophila melanogaster. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8MSU4.
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The mean pLDDT of this model is 82.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 53% |
| 70 to 90 | Confident: backbone generally right | 29% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
Component of a protein complex required for cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA (PubMed:18042462, PubMed:19450530). Involved in germline stem cell transit amplification, differentiation and mitosis-to-meiosis transition (PubMed:28190776)
Interacts with Cpsf73 and Cpsf100 forming a core cleavage factor required for both polyadenylated and histone mRNA processing. Interacts with Slbp and Lsm11
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4IMI | X-ray | 2.35 Å | A/C=19-351 |
| 3GS3 | X-ray | 2.4 Å | A=19-270 |
| 6NPW | X-ray | 2.49 Å | A/C=19-351 |
| 4IMJ | X-ray | 2.58 Å | A/C=19-351 |
| 4YGX | X-ray | 2.95 Å | A/C=19-351 |
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