Sesquipedalian-1 (PHETA1) is a 249-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8N4B1.
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The mean pLDDT of this model is 75.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 40% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 21% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane
Forms homodimers and heterodimers with PHETA2 (PubMed:21233288). Interacts with OCRL and INPP5B (PubMed:20133602, PubMed:21233288, PubMed:21666675). Interaction with OCRL may be important for endosomal morphology and function (By similarity)
Early endosome, Recycling endosome, Golgi apparatus, trans-Golgi network, Cytoplasmic vesicle, clathrin-coated vesicle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3QIS | X-ray | 2.3 Å | B=223-235 |
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