Leucine-zipper-like transcriptional regulator 1 (LZTR1) is a 840-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8N653.
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The mean pLDDT of this model is 80.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 48% |
| 70 to 90 | Confident: backbone generally right | 32% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras GTPases (M-Ras/MRAS, K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) and Ras-like protein RIT1 (PubMed:30442762, PubMed:30442766, PubMed:30481304, PubMed:40934300). Acts as a negative regulator of RAS-MAPK signaling by controlling Ras levels and decreasing Ras association with membranes (PubMed:30442762, PubMed:30442766, PubMed:30481304, PubMed:40934300)
Homodimer (PubMed:30442762). Component of the BCR(LZTR1) E3 ubiquitin ligase complex, at least composed of CUL3, LZTR1 and RBX1 (PubMed:30442762, PubMed:30442766). Interacts with the GDP-bound forms of RIT1 and Ras (M-Ras/MRAS, K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS); preferentially binds to RIT1 and M-Ras over other Ras isoforms (PubMed:30442762, PubMed:40934300). Interacts with RAF1…
Endomembrane system, Recycling endosome, Golgi apparatus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9MEZ | X-ray | 2.8 Å | B/D/F/H/J=50-422 |
| 9MEY | X-ray | 2.95 Å | B/D=50-422 |
| 9MF0 | X-ray | 3.3 Å | B/D/F/H/J=50-422 |
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