Kinesin-like protein KIF18A (KIF18A) is a 898-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8NI77.
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The mean pLDDT of this model is 67.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 38% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 34% |
What pLDDT means and how to read it
Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression
Interacts with CENPE and ESR1
Cell projection, ruffle, Cytoplasm, Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3LRE | X-ray | 2.2 Å | A/B=1-355 |
| 9YMG | X-ray | 2.41 Å | C/F=1-367 |
| 9DI0 | EM | 3.1 Å | A=2-374 |
| 5OGC | EM | 4.8 Å | K=1-374 |
| 7RSI | EM | 4.9 Å | C=1-353 |
| 5OCU | EM | 5.2 Å | K=1-374 |
| 5OAM | EM | 5.5 Å | K=1-374 |
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