Hydroxycarboxylic acid receptor 2 (HCAR2) is a 363-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8TDS4.
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The mean pLDDT of this model is 82.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 57% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding…
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8J6P | EM | 2.55 Å | R=8-301 |
| 8J6Q | EM | 2.6 Å | R=8-301 |
| 8JZ7 | EM | 2.6 Å | A=1-363 |
| 9IZC | EM | 2.68 Å | A=8-301 |
| 8IJA | EM | 2.69 Å | A=8-301 |
| 7ZL9 | X-ray | 2.7 Å | A=1-325 |
| 7ZLY | X-ray | 2.7 Å | A=1-325 |
| 9JKY | EM | 2.72 Å | A=8-301 |
| 9KT8 | EM | 2.73 Å | R=1-363 |
| 8J6R | EM | 2.76 Å | R=8-301 |
| 8I7V | EM | 2.77 Å | A=1-363 |
| 8J6J | EM | 2.8 Å | R=1-331 |
| 9KT7 | EM | 2.8 Å | R=1-363 |
| 8IHB | EM | 2.85 Å | R=2-363 |
| 8JHY | EM | 2.87 Å | A=1-363 |
| 9IQT | EM | 2.9 Å | R=1-363 |
| 8J6I | EM | 2.92 Å | R=1-311 |
| 8IHF | EM | 2.97 Å | R=2-363 |
| 8JIM | EM | 2.98 Å | E=1-363 |
| 8H2G | EM | 3.01 Å | A=1-363 |
Showing 20 of 40 experimental structures (best resolution first).
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