Mas-related G-protein coupled receptor member D (MRGPRD) is a 321-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8TDS7.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 85.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 55% |
| 70 to 90 | Confident: backbone generally right | 31% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
G protein-coupled receptor that acts as a mediator of peripheral pain and itch sensations (PubMed:15037633, PubMed:23091359, PubMed:35840655, PubMed:39580805). Activated by various ligands, such as beta-alanine, beta-aminoisobutyrate, angiotensin 1-7, alamandine and allantoin, causing a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:15037633, PubMed:23091359, PubMed:35840655, PubMed:39580805). MRGPRD is both coupled to G(q) and G(i) G proteins: G(q) coupling activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers, while…
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7Y15 | EM | 2.9 Å | R=5-321 |
| 9DQJ | EM | 2.9 Å | A=2-321 |
| 9DQH | EM | 2.92 Å | A=2-321 |
| 7Y12 | EM | 3.1 Å | R=5-321 |
| 7Y13 | EM | 3.1 Å | R=5-321 |
| 7Y14 | EM | 3.2 Å | R=5-321 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.