Voltage-dependent calcium channel gamma-8 subunit (Cacng8) is a 421-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8VHW5.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 58.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 13% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 49% |
What pLDDT means and how to read it
Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state
Interacts with CACNA1C. Identified in a complex with the L-type calcium channel subunits CACNA1C, CACNA2D1 and either CACNB1 or CACNB2 (By similarity). Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG7. Interacts with CNIH2 (By similarity). Found in a complex…
Cell membrane, Postsynaptic density membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8AYN | EM | 2.8 Å | I/J=2-417 |
| 7OCE | EM | 3.1 Å | I/J=2-417 |
| 8AYL | EM | 3.2 Å | I/J=2-417 |
| 8AYM | EM | 3.3 Å | I/J=2-417 |
| 8AYO | EM | 3.3 Å | I/J=2-417 |
| 7OCA | EM | 3.4 Å | I/J=2-417 |
| 7OCD | EM | 3.5 Å | I/J=2-417 |
| 7QHB | EM | 3.5 Å | I/J=2-417 |
| 7OCF | EM | 3.6 Å | I/J=2-417 |
| 7QHH | EM | 3.6 Å | I/J=2-417 |
| 6QKC | EM | 4.1 Å | I/J=2-417 |
| 6QKZ | EM | 6.3 Å | I/J=2-417 |
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