Boophilin-H2 is a 142-residue protein from Rhipicephalus microplus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8WPI2.
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The mean pLDDT of this model is 89.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 78% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Midgut thrombin inhibitor that plays a major role in keeping the midgut microenvironment at low hemostatic and inflammatory tonus (By similarity) (PubMed:18286181). Also inhibits FXIa (F11), kallikrein (KLK1), neutrophil elastase (ELANE) and cathepsin G (CTSG), which play a role in the contact pathway of the coagulation cascade (By similarity) (PubMed:18286181). Also abrogates platelet aggregation by cathepsin G and plasmin, and attenuates tissue factor (F3) pathway inhibitor cleavage by elastase (By similarity) (PubMed:18286181). In vivo, inhibits thrombosis and promotes bleeding in mice (By similarity)
Interacts with host thrombin and trypsin
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2ODY | X-ray | 2.35 Å | E/F=16-142 |
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