Histone-lysine N-methyltransferase SETD7 (SETD7) is a 366-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8WTS6.
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The mean pLDDT of this model is 94.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 87% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 (PubMed:11779497, PubMed:11850410, PubMed:12540855, PubMed:12588998, PubMed:16141209). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:12540855, PubMed:12588998, PubMed:16141209). Plays a central role in the transcriptional activation of genes such as collagenase or insulin (PubMed:12588998, PubMed:16141209). Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription (PubMed:16141209). Also has methyltransferase activity toward non-histone proteins such as CGAS, GLI3, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the…
Interacts with IPF1/PDX-1
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2F69 | X-ray | 1.3 Å | A=110-366 |
| 3M58 | X-ray | 1.4 Å | A=110-366 |
| 3CBP | X-ray | 1.42 Å | A=111-366 |
| 3M55 | X-ray | 1.55 Å | A=110-366 |
| 5EG2 | X-ray | 1.55 Å | A=110-366 |
| 4J7F | X-ray | 1.59 Å | A=110-366 |
| 3M54 | X-ray | 1.6 Å | A=110-366 |
| 4J8O | X-ray | 1.63 Å | A=110-366 |
| 3CBO | X-ray | 1.65 Å | A=111-366 |
| 3M56 | X-ray | 1.65 Å | A=110-366 |
| 3CBM | X-ray | 1.69 Å | A=111-366 |
| 3OS5 | X-ray | 1.69 Å | A=111-366 |
| 5YLT | X-ray | 1.69 Å | A=111-366 |
| 1N6A | X-ray | 1.7 Å | A=108-366 |
| 3M57 | X-ray | 1.7 Å | A=110-366 |
| 3M59 | X-ray | 1.7 Å | A=110-366 |
| 4J83 | X-ray | 1.7 Å | A=110-366 |
| 4JDS | X-ray | 1.7 Å | A/B/C/D=109-366 |
| 1O9S | X-ray | 1.75 Å | A/B=108-366 |
| 1XQH | X-ray | 1.75 Å | A/E=108-366 |
Showing 20 of 32 experimental structures (best resolution first).
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