Histone deacetylase 7 (HDAC7) is a 952-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8WUI4.
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The mean pLDDT of this model is 62.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 36% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 51% |
What pLDDT means and how to read it
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in…
Interacts with HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, NCOR1, NCOR2, SIN3A, SIN3B, RBBP4, RBBP7, MTA1L1, SAP30 and MBD3 (PubMed:11466315). Interacts with KAT5 and EDNRA (PubMed:11262386, PubMed:12551922). Interacts with the 14-3-3 protein YWHAE, MEF2A, MEF2B and MEF2C. Interacts with ZMYND15 (By similarity). Interacts with KDM5B (PubMed:17373667). Interacts with PML (PubMed:22155184). Interacts with…
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3C10 | X-ray | 2.0 Å | A/B/C=482-903 |
| 3C0Y | X-ray | 2.1 Å | A/B/C=482-903 |
| 3C0Z | X-ray | 2.1 Å | A/B/C=482-903 |
| 8Q9Q | X-ray | 2.11 Å | X=83-97 |
| 3ZNR | X-ray | 2.4 Å | A/B/C=482-903 |
| 3ZNS | X-ray | 2.45 Å | A/B/C=482-903 |
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