Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGNT1) is a 660-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8WZA1.
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The mean pLDDT of this model is 89.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 81% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins (PubMed:11709191, PubMed:27493216, PubMed:28512129). Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties (PubMed:11709191, PubMed:27493216). Is specific for alpha linked terminal mannose and does not have MGAT3, MGAT4, MGAT5, MGAT7 or MGAT8 activity
Interacts with DAG1 (via O-linked mannose moiety) (PubMed:27493216). Interacts (via transmembrane domain) with FKTN; the interaction is direct and is required for normal location in Golgi membranes (PubMed:17034757)
Golgi apparatus membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5GGN | X-ray | 1.21 Å | A/B=92-250 |
| 5GGL | X-ray | 1.27 Å | A/B=92-250 |
| 5GGK | X-ray | 1.3 Å | A/B=92-250 |
| 5XFC | X-ray | 1.4 Å | A/B=92-250 |
| 5GGJ | X-ray | 1.42 Å | A/B=92-250 |
| 5GGO | X-ray | 1.5 Å | A/B=92-250 |
| 5GGP | X-ray | 1.6 Å | A/B=92-250 |
| 5GGF | X-ray | 2.49 Å | A/B/C=92-660 |
| 5GGI | X-ray | 2.6 Å | A/B=92-660 |
| 5GGG | X-ray | 3.0 Å | A=92-660 |
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