Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5 (dim-5) is a 331-residue protein from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8X225.
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The mean pLDDT of this model is 88.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 70% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Histone methyltransferase that specifically trimethylates histone H3 to form H3K9me3. H3K9me3 marks chromatin regions for DNA methylation (PubMed:11713521, PubMed:12372305, PubMed:12679815, PubMed:12887903). Dim-5 recognizes Arg-8 to Gly-12 of the H3 tail with Thr-11 and Gly-12 being the most important specificity determinants, the recognition of whcih is important to distinguish H3K9 from H3K27 and H4K20 (PubMed:18215768)
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
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