Effector protein NleF (nleF) is a 189-residue protein from Escherichia coli O157:H7. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8XAL7.
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The mean pLDDT of this model is 86.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 71% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
Effector protein that alters host cell physiology and promotes bacterial survival in host tissues. Inhibits the catalytic activity of human CASP4, CASP8 and CASP9, and thereby inhibits apoptosis of infected host cells
Monomer. Interacts (via C-terminus) with human CASP4, CASP8 and CASP9
Secreted, Host cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3V3K | X-ray | 3.49 Å | B/D/F/H/J/L/N/P=25-189 |
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