Lysophosphatidic acid receptor 1 (LPAR1) is a 364-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q92633.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 83.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 65% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Receptor for lysophosphatidic acid (LPA) (PubMed:19306925, PubMed:25025571, PubMed:26091040, PubMed:9070858). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C…
Interacts with RALA and GRK2 (PubMed:19306925). Interacts with GNAQ and GNA13. Interacts with CD14; the interaction is enhanced by exposure to bacterial lipopolysaccharide (LPS) (By similarity)
Cell surface, Cell membrane, Endosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7TD0 | EM | 2.83 Å | R=2-340 |
| 9J5V | EM | 2.86 Å | R=2-364 |
| 4Z35 | X-ray | 2.9 Å | A=2-232, A=248-326 |
| 4Z36 | X-ray | 2.9 Å | A=2-232, A=248-326 |
| 4Z34 | X-ray | 3.0 Å | A=2-232, A=248-326 |
| 9IZG | EM | 3.04 Å | R=2-364 |
| 9IZH | EM | 3.04 Å | R=2-364 |
| 7TD1 | EM | 3.08 Å | R=2-340 |
| 7TD2 | EM | 3.11 Å | R=2-340 |
| 9IZF | EM | 3.14 Å | R=2-364 |
| 7YU4 | EM | 3.3 Å | A=2-364 |
| 7YU5 | EM | 3.3 Å | R=2-364 |
| 7YU3 | EM | 3.4 Å | R=2-364 |
| 7YU6 | EM | 3.5 Å | R=2-364 |
| 7YU7 | EM | 3.8 Å | R=2-364 |
| 7YU8 | EM | 4.5 Å | R=2-364 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.