Zinc finger protein ubi-d4 (DPF2) is a 391-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q92785.
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The mean pLDDT of this model is 69.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 30% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 18% |
| Below 50 | Very low: often disordered regions | 28% |
What pLDDT means and how to read it
Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684)
Interacts with the nucleosomes, in particular nucleosomes bearing histone H3 crotonylated at 'Lys-14' (H3K14cr) for which DPF2 has high affinity (PubMed:27775714). Also interacts (via PHD-type zinc finger domains) with histone H3 butyrylated at 'Lys-14' (H3K14bu), histone H3 propionylated at 'Lys-14' (H3K14pr), and histone H3 acetylated at 'Lys-14' (H3K14ac) (PubMed:27775714, PubMed:28533407,…
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5VDC | X-ray | 1.6 Å | A=270-391 |
| 3IUF | X-ray | 1.8 Å | A=203-249 |
| 5B79 | X-ray | 2.6 Å | A=270-391 |
| 6LTH | EM | 3.0 Å | R=1-391 |
| 9RL4 | EM | 3.5 Å | R=1-391 |
| 6LTJ | EM | 3.7 Å | R=1-100, R=209-391 |
| 9RN2 | EM | 4.1 Å | R=1-391 |
| 9RMC | EM | 4.2 Å | R=1-391 |
| 9RN1 | EM | 5.9 Å | R=1-391 |
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