Protein Jumonji (JARID2) is a 1246-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q92833.
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The mean pLDDT of this model is 61.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 32% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 50% |
What pLDDT means and how to read it
Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:20075857). Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin (PubMed:20075857, PubMed:29499137, PubMed:31959557). Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (PubMed:20075857). In cardiac cells, it is required to repress expression of cyclin-D1…
Associates with the PRC2 complex, which consists of the core components EED, EZH1 or EZH2, SUZ12, and RBBP4, and various combinations of accessory subunits including AEBP2, JARID2, PHF19, MTF2 and EPOP (PubMed:29499137, PubMed:31959557). Found in a monomeric PRC2.2 (class 2) complex consisting of at least SUZ12, RBBP4, AEBP2 and JARID2 (PubMed:29499137). Facilitates nucleosome binding of the…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4X3E | X-ray | 2.3 Å | B=110-121 |
| 6NQ3 | X-ray | 2.89 Å | D/H=147-165 |
| 5WAI | X-ray | 2.9 Å | D/H=147-165 |
| 5HYN | X-ray | 2.95 Å | E/J/P/U=110-121 |
| 8VMI | EM | 3.1 Å | F=1-1246 |
| 8VNV | EM | 3.1 Å | B=2-450 |
| 9C8U | EM | 3.1 Å | E=139-169 |
| 9DCH | EM | 3.4 Å | E/L=119-450 |
| 5LS6 | X-ray | 3.47 Å | Q/R/S/T=110-120 |
| 6C24 | EM | 3.5 Å | B/E=106-450 |
| 6WKR | EM | 3.5 Å | B/E=1-450 |
| 8VML | EM | 3.5 Å | B=1-1246 |
| 8VNZ | EM | 3.5 Å | B=2-450 |
| 6C23 | EM | 3.9 Å | B/E=106-450 |
| 7KSO | EM | 3.9 Å | F=1-1246 |
| 8TB9 | EM | 4.0 Å | B=119-450 |
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