Growth hormone secretagogue receptor type 1 (GHSR) is a 366-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q92847.
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The mean pLDDT of this model is 81.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 51% |
| 70 to 90 | Confident: backbone generally right | 27% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
G protein-coupled receptor specific to ghrelin, an appetite-regulating peptide hormone commonly found in stomach (PubMed:35027551, PubMed:39833471). Upon activation, stimulates appetite and promotes growth hormone secretion (PubMed:10604470, PubMed:11322507, PubMed:35027551, PubMed:39833471). Ghrelin binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (By similarity). GHSR is coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (By similarity). Also binds other growth hormone releasing peptides…
Interacts with the heterotrimeric G protein complex composed of 3 units, alpha, beta and gamma; this complex may consist of GNB1 and GNG2 (PubMed:35027551, PubMed:39833471). Interacts with DRD1; forms a heteromer with DRD1 in hippocampal neurons (By similarity). Interacts with DRD2; forms a heteromer with DRD2 in neurons (By similarity)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9UY3 | EM | 2.52 Å | R=1-366 |
| 9V2N | EM | 2.63 Å | R=1-366 |
| 7NA7 | EM | 2.7 Å | R=1-366 |
| 7NA8 | EM | 2.7 Å | R=1-366 |
| 7W2Z | EM | 2.8 Å | R=1-366 |
| 7F9Y | EM | 2.9 Å | R=1-366 |
| 8JSR | EM | 2.9 Å | R=2-366 |
| 7F83 | X-ray | 2.94 Å | A/B=35-243, A/B=253-342 |
| 7F9Z | EM | 3.2 Å | R=1-366 |
| 6KO5 | X-ray | 3.3 Å | A=29-346 |
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