Urocortin-3 (UCN3) is a 161-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q969E3.
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The mean pLDDT of this model is 65.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 12% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 47% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
Hormone that plays a central role in whole body adaptation to stress (PubMed:11329063, PubMed:11416224). Released by the hypothalamus primarily in response to physical or psychological stress and acts by binding to CRH receptor CRHR2 (PubMed:11329063, PubMed:11416224, PubMed:20966082, PubMed:26350463). UCN3-dependent signaling plays a key role in the metabolic regulation and energy homeostasis in responses to stress, acting as an anxiolytic (PubMed:11329063, PubMed:11416224). Promotes energy balance by reducing food intake, improving insulin sensitivity and managing blood glucose levels in response to metabolic stress (By similarity). In contrast to CRH and UCN, does not activate the…
Secreted
Compare the prediction with experimentally determined structures of the same protein:
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