Baculoviral IAP repeat-containing protein 7 (BIRC7) is a 298-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96CA5.
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The mean pLDDT of this model is 71.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 48% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 35% |
What pLDDT means and how to read it
Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control (PubMed:11024045, PubMed:11084335, PubMed:11162435, PubMed:16729033, PubMed:17294084). Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity (PubMed:11024045, PubMed:16729033). As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival (PubMed:16729033). May contribute to caspase inhibition, by blocking the…
Binds to CASP9. Interaction with DIABLO/SMAC via the BIR domain disrupts binding to CASP9 and apoptotic suppressor activity. Interacts with TAB1. In vitro, interacts with CASP3 and CASP7 via its BIR domain
Nucleus, Cytoplasm, Golgi apparatus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2I3H | X-ray | 1.62 Å | A/B=63-171 |
| 3GT9 | X-ray | 1.7 Å | A/B=63-172 |
| 3GTA | X-ray | 1.7 Å | A/B=63-172 |
| 1TW6 | X-ray | 1.71 Å | A/B=63-171 |
| 3UW5 | X-ray | 1.71 Å | A/B=63-159 |
| 3F7H | X-ray | 1.8 Å | A/B=63-172 |
| 3F7I | X-ray | 1.9 Å | A/B=63-172 |
| 4AUQ | X-ray | 2.18 Å | B/E=239-298 |
| 1OXN | X-ray | 2.2 Å | A/B/C/D/E=63-179 |
| 1OXQ | X-ray | 2.3 Å | A/B/C/D/E=63-179 |
| 2I3I | X-ray | 2.3 Å | A/B=63-171 |
| 3F7G | X-ray | 2.3 Å | A/B/C/D/E=63-179 |
| 1OY7 | X-ray | 2.7 Å | A/B/C/D/E=63-179 |
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