PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 (PABIR1) is a 287-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96E09.
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The mean pLDDT of this model is 59.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 7% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 55% |
| Below 50 | Very low: often disordered regions | 28% |
What pLDDT means and how to read it
Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481, PubMed:33108758, PubMed:38123684). Inhibits PP2A activity by blocking the substrate binding site on PPP2R2A and the active site of PPP2CA (PubMed:38123684). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (PubMed:33108758)
Interacts with PPP2CA and PPP2R1A (PubMed:27588481). Interacts (via its N-terminus) with PPP2R2A; the interaction is direct and this interaction inhibits PP2A activity (PubMed:27588481, PubMed:33108758, PubMed:38123684). The CHEK1-mediated Ser-37 phosphorylated form interacts with 14-3-3 proteins (PubMed:33108758)
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8TWE | EM | 2.55 Å | D=29-120 |
| 8TWI | EM | 2.69 Å | D=29-120 |
| 8SO0 | EM | 2.8 Å | D=29-120 |
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