DDB1- and CUL4-associated factor 5 (DCAF5) is a 942-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96JK2.
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The mean pLDDT of this model is 60.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 30% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 50% |
What pLDDT means and how to read it
Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4) (PubMed:29691401, PubMed:30442713). The complex CRL4-DCAF5 is involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1 (PubMed:29691401, PubMed:30442713)
Interacts with DDB1, CUL4A or CUL4B (PubMed:29691401). Interacts with L3MBTL3 (PubMed:29691401). Interacts with DNMT1 (PubMed:29691401). Interacts with E2F1 (PubMed:29691401). Interacts with SOX2 (By similarity)
Compare the prediction with experimentally determined structures of the same protein:
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