Protein fem-1 homolog C (FEM1C) is a 617-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96JP0.
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The mean pLDDT of this model is 94.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 88% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29775578, PubMed:29779948, PubMed:33398168, PubMed:33398170, PubMed:38326650). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29775578, PubMed:29779948, PubMed:33398168, PubMed:33398170). The CRL2(FEM1C) complex specifically recognizes proteins with an arginine at…
Component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, also named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex, composed of CUL2, Elongin BC (ELOB and ELOC), RBX1 and substrate-specific adapter FEM1C
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6XKC | X-ray | 2.03 Å | A/B/C/D/E/F=1-244 |
| 6LF0 | X-ray | 2.11 Å | A/B=1-403 |
| 6LE6 | X-ray | 2.33 Å | A/B=1-390 |
| 6LDP | X-ray | 2.35 Å | A/B=1-390 |
| 6LEN | X-ray | 2.38 Å | A/B=1-390 |
| 6LEY | X-ray | 2.39 Å | A/B=1-390 |
| 7JYA | X-ray | 2.46 Å | A/B/C=2-371 |
| 6LBG | X-ray | 2.51 Å | A/B=1-390 |
| 6LBN | X-ray | 2.9 Å | A/B=1-390 |
| 9UA3 | EM | 3.28 Å | A/E=1-617 |
| 8Q7R | EM | 3.71 Å | H=1-617 |
| 8PQL | EM | 3.76 Å | H=1-617 |
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