Histone-lysine N-methyltransferase EHMT2 (EHMT2) is a 1210-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96KQ7.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 68.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 44% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 39% |
What pLDDT means and how to read it
Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones (PubMed:11316813, PubMed:20084102). Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication (PubMed:22387026). Also weakly methylates 'Lys-27' of histone H3 (H3K27me) (PubMed:11316813). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these…
Heterodimer; heterodimerizes with EHMT1/GLP (PubMed:16702210). Interacts with GFI1B and WIZ (PubMed:16688220, PubMed:16702210). Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EHMT1, RING1, RNF2, MBLR, L3MBTL2 and YAF2 (PubMed:12004135). Part of a complex composed of TRIM28, HDAC1, HDAC2 and EHMT2 (PubMed:21549307). Interacts with UHRF1…
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5VSC | X-ray | 1.4 Å | A/B=916-1190 |
| 7XUD | X-ray | 1.45 Å | A/B=913-1193 |
| 5JIY | X-ray | 1.48 Å | A/B=916-1189 |
| 7X73 | X-ray | 1.49 Å | A/B=913-1193 |
| 8Z7C | X-ray | 1.52 Å | A/B=913-1193 |
| 8Z7E | X-ray | 1.54 Å | A/B=913-1193 |
| 8Z7D | X-ray | 1.58 Å | A/B=913-1193 |
| 5VSE | X-ray | 1.6 Å | A/B=917-1190 |
| 5JHN | X-ray | 1.67 Å | A/B=916-1189 |
| 7XUC | X-ray | 1.67 Å | A/B=913-1193 |
| 3K5K | X-ray | 1.7 Å | A/B=913-1193 |
| 5T0K | X-ray | 1.7 Å | A/B=913-1193 |
| 5JJ0 | X-ray | 1.72 Å | A/B=916-1189 |
| 5TTF | X-ray | 1.72 Å | A/B/C/D=913-1193 |
| 5V9I | X-ray | 1.74 Å | A/B/C/D=913-1193 |
| 2O8J | X-ray | 1.8 Å | A/B/C/D=913-1193 |
| 7DCF | X-ray | 1.8 Å | A/B=913-1193 |
| 9KLB | X-ray | 1.81 Å | A/B=913-1193 |
| 5JIN | X-ray | 1.85 Å | A/B=916-1189 |
| 9WRI | X-ray | 1.85 Å | C=881-893 |
Showing 20 of 34 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.