Leucine-rich repeat-containing protein 7 (LRRC7) is a 1537-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96NW7.
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The mean pLDDT of this model is 51.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 26% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 66% |
What pLDDT means and how to read it
Adapter protein that is required for correct postsynapse architecture and regulates postsynaptic plasticity through interactions with different partners (PubMed:11729199, PubMed:39256359). Through its interaction with CACNA1C, it enhances trafficking of voltage-dependent L-type calcium channels to the dendritic cell membrane and increases channel postsynaptic clustering, thereby facilitating excitatory calcium signaling (By similarity). It also serves as a scaffold that brings CAMK2A and PPP1CA into close proximity, probably facilitating rapid dephosphorylation of CAMK2A by PPP1CA and influencing CAMK2A-mediated regulation of postsynaptic plasticity (PubMed:39256359). Necessary for DISC1…
Interacts with CNKSR2 and DLG4 (By similarity). Interacts with CTNND2/Catenin delta-2 (PubMed:11729199, PubMed:39256359). Forms a complex with N-cadherin through CTNND2 (PubMed:11729199). Interacts with CAMK2A and PPP1CA (PubMed:28130356, PubMed:39256359); the interaction may facilitate rapid CAMK2A dephosphorylation by PPP1CA by bringing CAMK2A and PPP1CA into close proximity (PubMed:39256359).…
Cytoplasm, Postsynaptic density, Cell projection, dendritic spine, Postsynapse
Compare the prediction with experimentally determined structures of the same protein:
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