2-oxoglutarate receptor 1 (OXGR1) is a 337-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96P68.
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The mean pLDDT of this model is 86.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 60% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
G protein-coupled receptor for dicarboxylates and amino dicarboxylates, such as alpha-ketoglutarate, itaconate and leukotriene E4 (PubMed:15141213, PubMed:36571463, PubMed:36919698, PubMed:41413034, PubMed:41791372). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (PubMed:41413034, PubMed:41791372). OXGR1 is coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:36919698, PubMed:41413034, PubMed:41791372). Activation by alpha-ketoglutarate produced by proximal tubule renal…
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9VMO | EM | 2.4 Å | R=26-320 |
| 9VMP | EM | 2.5 Å | R=26-320 |
| 9VMN | EM | 2.6 Å | R=26-320 |
| 9VO2 | EM | 2.7 Å | R=1-337 |
| 8YYX | EM | 2.84 Å | E=1-337 |
| 9UK2 | EM | 2.9 Å | A=1-337 |
| 8YYW | EM | 3.16 Å | E=1-337 |
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