Serine/threonine-protein kinase SMG1 (SMG1) is a 2392-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96Q15.
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The mean pLDDT of this model is 76.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 16% |
| 70 to 90 | Confident: backbone generally right | 62% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a…
Component of the SMG1C complex composed of SMG1, SMG8 and SMG9; the recruitment of SMG8 to SMG1 N-terminus induces a large conformational change in the SMG1 C-terminal head domain containing the catalytic domain (PubMed:33205750). Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. Part of a complex composed of SMG1, DHX34 and UPF1; within the complex DHX34 acts as a scaffolding…
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7PW8 | EM | 2.82 Å | A=311-3661 |
| 6Z3R | EM | 2.97 Å | A=259-3661 |
| 7PW6 | EM | 3.05 Å | A=766-3661 |
| 7PW9 | EM | 3.12 Å | A=311-3661 |
| 7PW4 | EM | 3.27 Å | A=311-3661 |
| 7PW5 | EM | 3.4 Å | A=311-3661 |
| 6L54 | EM | 3.43 Å | A=1-3661 |
| 6SYT | EM | 3.45 Å | A=311-3661 |
| 7PW7 | EM | 3.59 Å | A=311-3661 |
| 6L53 | EM | 3.63 Å | A=1-3661 |
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