viral G-protein coupled receptor (ORF74) is a 342-residue protein from Human herpesvirus 8 type P. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: Q98146.
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The mean pLDDT of this model is 79.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 34% |
| 70 to 90 | Confident: backbone generally right | 45% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
Receptor that signals constitutively via several signaling pathways including PI3K/AKT as well as mitogen- and stress-activated/MAP kinases. Promotes host cell proliferation and survival, modulates cell migration, stimulates angiogenesis, and recruits inflammatory cells, both in expressing cells and in neighboring cells. Maintains chronic activation of NF-kappa-B via interaction with host CADM1 (PubMed:29698475)
Interacts with protein K7; this interaction promotes vGPCR proteasomal degradation (PubMed:18802460). Interacts with host CADM1; this interaction is essential for chronic NF-kappa-B activation (PubMed:29698475)
Host cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8K4P | EM | 2.81 Å | A=47-340 |
| 8W1A | EM | 2.89 Å | A/B=1-340 |
| 9EJC | EM | 2.98 Å | E=1-340 |
| 8K4O | EM | 3.01 Å | E=5-337 |
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