Unconventional myosin-Va (Myo5a) is a 1853-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q99104.
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The mean pLDDT of this model is 76.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 24% |
| 70 to 90 | Confident: backbone generally right | 49% |
| 50 to 70 | Low: treat with caution | 16% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyze ATP in the presence of actin, which is essential for its function as a motor protein (By similarity). Involved in melanosome transport (PubMed:1996138). Also mediates the transport of vesicles to the plasma membrane (PubMed:22908308). May also be required for some polarization process involved in dendrite formation (By similarity)
May be a homodimer, which associates with multiple calmodulin or myosin light chains (PubMed:17151196). Interacts with RIPL2, the interaction is required for its role in dendrite formation (PubMed:23798443). Interacts with MLPH (PubMed:11887186). Interacts with SYTL4 (PubMed:23798443). Interacts with MYRIP (PubMed:12221080). Interacts with RAB10; mediates the transport to the plasma membrane of…
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6KU0 | X-ray | 1.6 Å | A/C=1469-1853 |
| 4KP3 | X-ray | 2.4 Å | A/B=1469-1853 |
| 2IX7 | X-ray | 2.5 Å | C=763-820 |
| 3WB8 | X-ray | 2.5 Å | A/B/C/D/E/F/G/H=1469-1853 |
| 4ZLK | X-ray | 2.5 Å | A=1-791 |
| 8RBF | EM | 4.2 Å | A=5-767 |
| 8R9V | EM | 4.4 Å | A=1-797 |
| 7YV9 | EM | 4.78 Å | A/H/X/Y=1-1853 |
| 8RBG | EM | 4.9 Å | A=1-797 |
| 8OF8 | EM | 7.5 Å | M=1-907 |
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