Bcl-2-binding component 3 (Bbc3) is a 193-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q99ML1.
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The mean pLDDT of this model is 59.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 11% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 38% |
| Below 50 | Very low: often disordered regions | 39% |
What pLDDT means and how to read it
Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (By similarity). Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis (By similarity). Regulates ER stress-induced neuronal apoptosis (PubMed:21159964, PubMed:22761832)
Interacts with MCL1 and BCL2A1 (PubMed:18462686, PubMed:18589438). Interacts with BCL2 and BCL2L1/BCL-XL (By similarity). Interacts (via BH3 domain) with NOL3 (via CARD domain); this interaction prevents BBC3 association with BCL2 and results in CASP8 activation (By similarity)
Mitochondrion
Compare the prediction with experimentally determined structures of the same protein:
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