Sclerostin (SOST) is a 213-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BQB4.
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The mean pLDDT of this model is 70.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 25% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 52% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation
Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6
Secreted, extracellular space, extracellular matrix
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3SOV | X-ray | 1.27 Å | Z=115-121 |
| 6L6R | X-ray | 3.8 Å | C/D=24-177 |
| 2K8P | NMR | A=25-213 |
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