Pygopus homolog 2 (PYGO2) is a 406-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BRQ0.
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The mean pLDDT of this model is 55.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 12% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 32% |
| Below 50 | Very low: often disordered regions | 52% |
What pLDDT means and how to read it
Involved in signal transduction through the Wnt pathway
Binds to BCL9 via the PHD-type zinc finger motif, and thereby becomes part of the nuclear beta-catenin/TCF complex
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4UP0 | X-ray | 1.28 Å | A=327-387 |
| 4UP5 | X-ray | 1.65 Å | A=327-387 |
| 2XB1 | X-ray | 1.9 Å | A/C=325-387 |
| 8HIB | X-ray | 2.45 Å | D=59-84 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.