Spindlin interactor and repressor of chromatin-binding protein (SPINDOC) is a 381-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BUA3.
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The mean pLDDT of this model is 51.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 9% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 68% |
What pLDDT means and how to read it
Chromatin protein that stabilizes SPIN1 and enhances its association with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3) (PubMed:33574238). Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity (PubMed:34737271)
Interacts with SPIN1, SPIN2A, SPIN2B, SPIN3 and SPIN4 (PubMed:29061846, PubMed:33574238). Interacts with TCF7L2 in a SPIN1-dependent manner (PubMed:29061846). Interacts with PARP1; promoting PARP1 ADP-ribosyltransferase activity (PubMed:34737271)
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7CNA | X-ray | 1.6 Å | B/E=254-283 |
| 7E9M | X-ray | 2.5 Å | B/D=256-282 |
| 7EA1 | X-ray | 2.7 Å | B/D=228-239 |
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