Cell cycle regulator of non-homologous end joining (CYREN) is a 157-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BWK5.
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The mean pLDDT of this model is 65.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 17% |
| 70 to 90 | Confident: backbone generally right | 16% |
| 50 to 70 | Low: treat with caution | 49% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
Cell-cycle-specific regulator of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair, which can act both as an activator or inhibitor of NHEJ, depending on the cell cycle phase (PubMed:24610814, PubMed:28959974). Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present (PubMed:28959974). Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination (PubMed:28959974).…
Interacts (via KBM motif) with XRCC5/Ku80 and XRCC6/Ku70 heterodimer (PubMed:24610814, PubMed:27063109, PubMed:28959974). Interacts (via XLF motif) with TRIM28/KAP1, ATM, MRE11, NBN and RAD50 (By similarity). Interacts with splicing factor SF3B1 (PubMed:37813856). Interacts with ERCC6L2; this interaction is DNA independent (PubMed:32355287)
Cytoplasm, Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6TYU | X-ray | 1.47 Å | B=6-21 |
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